One of the best kept secrets by Bay Area locals, Interstate 280 doubles as a fast commuter road and the most beautiful Interstate in the region. Start by puttering down 19th Avenue through the City. After you pass San Francisco State University and off the city streets, get your speed on. The speed limit on I280 is 65mph, but you’ll see locals driving much faster .
But don’t jet down the asphalt so fast that you miss the change from cityscape to rolling hills dotted with native oaks, elegant mansions, and the occasional herd of cows. The lovely views continue south until Cupertino, where the suburban industry of the Silicon Valley crowds in on the freeway until it becomes I680 and loops around to Milpitas, becoming less pretty and crammed with commuters.
A few great places to stop include, from north to south (northwest to southeast if you’re using a compass)…read more at Oyster Locals